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Anticellular Effects of 9-(2-Hydroxyethoxymethyl) Guanine Against Herpes Simplex Virus-transformed Cells

Department of Microbiology and Specialized Cancer Research Center The Pennsylvania State University College of Medicine Hershey, Pennsylvania 17033, U.S.A.

The guanine derivative 9-(2-hydroxyethoxymethyl) guanine (acycloguanosine), a potent inhibitor of herpes simplex virus (HSV) multiplication, was found to have marked anticellular activity against HSV-transformed thymidine kinase-positive cells. HSV type 1-transformed cells were more sensitive to the drug than HSV type 2-transformed cells.

Received 26 January 1979; accepted 30 May 1979.

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