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Protease Activity on the Surface of HSV-infected Cells

Institute for Medical Microbiology and Division of Experimental Virology University of Mainz 6500 Mainz, West Germany

Monolayers of primary rabbit kidney cells infected with HSV type 1 bound lymphoblastoid (Raji) cells, to which the third component (C3) of the complement system had been attached (Raji-C3). This induction of cell contact did not occur on non-infected monolayers and was dependent on C3. The interaction could be suppressed by the presence of protease inhibitors (1 mM-TLCK or-PMSF). The results are interpreted as indicating de novo expression of protease activity on the surface of HSV-infected cells. This protease is characterized by its potential to activate C3 and its inhibition by TLCK.

Received 19 January 1979; accepted 4 June 1979.