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Differentiation of the Haemagglutinin Genes of Variant Influenza Viruses by RNA-RNA Hybridization

National Institute for Medical Research Mill Hill, London NW7 1AA, U.K.

The genetic compositions of four antigenic variants of A/Memphis/1/71 (H3N2) influenza virus, which were selected by growth in the presence of monoclonal antibodies against the haemagglutinin, were compared. The results indicate that the mutant haemagglutinin genes can be differentiated by polyacrylamide gel electrophoresis of the double stranded RNA hybrids formed between virion RNA and transcripts isolated from infected cells.

^* Permanent address: St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38101, U.S.A.

Received 24 May 1979; accepted 15 June 1979.