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Cross Protection among Togaviruses in Nude Mice and Littermates

Department of Microbiology, The University of Tennessee, Knoxville, Tennessee 37916, U.S.A.

After immunization with Sindbis virus, T-cell deficient nude mice, compared to normal littermates, were equally protected against challenge with Sindbis virus. However, the nude mice showed about one-tenth the protection observed with normal littermates after challenge with Semliki Forest virus at a dose of 100 LD₅₀. This is consistent with our previous interpretation that sensitized T-cell populations play a major role in cross protection between the two togaviruses. The remaining low level of specific cross protection in nude mice (detectable only at a challenge dose of 10 LD₅₀) could not be attributed to an anamnestic response of neutralizing antibody to the challenge virus or to an effective antibody-dependent, complement-mediated cytolysis of infected cells in vivo. Other possible compensatory mechanisms to explain the low level of specific cross protection in nude mice are discussed.

^* Author to whom requests for reprints should be addressed.

Received 29 December 1978; accepted 30 March 1979.

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