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Selective Replication of Transformation-defective Avian Sarcoma Virus Mutants in Duck Embryo Fibroblasts

Department of Tumor Viruses, Research Institute for Microbial Diseases, Osaka University, Yamada-kami, Suita City, Osaka, Japan

When an avian sarcoma virus (ASV), subgroup C Bratislava 77 (B77-C) was inoculated into duck embryo fibroblast cultures (DEF) at a m.o.i. of 0.02, its replication was retarded by about 3 days compared with that in chick embryo fibroblast cultures (CEF). A transformation-defective (td) mutant was isolated during this period of retardation. Unlike the sarcoma virus, this td mutant replicated in both DEF and CEF with no retardation, even at a low m.o.i. The subgroup C Prague strain of Rous sarcoma virus (PR-C), which can infect DEF, also replicated in DEF slower than its td mutant, tdPR-C, at a m.o.i. of 0.02.

Received 29 December 1978; accepted 30 March 1979.

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