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Comparison of the Antibodies Elicited by the Individual Structural Polypeptides of Foot-and-Mouth Disease and Polio Viruses

Central Veterinary Institute Houtribweg 39, 0221 RA Lelystad, The Netherlands

D. J. Rowlands and F. Brown

Animal Virus Research Institute Pirbright, Woking, Surrey GU24 0NN United Kingdom

Antibody produced against preparations of VP₁, one of the four structural polypeptides of foot-and-mouth disease virus, neutralized the virus and reacted with both full and empty particles in radioimmunoassays (RIA). Antiserum against VP₂ reacted with artificial empty particles of the virus but not with full particles. In contrast, none of the individual polypeptides of poliovirus produced antisera which neutralized the virus nor reacted with it in RIA. However, antisera produced with VP₁ and VP₂ reacted with artificial empty particles in RIA.

Received 17 May 1979; accepted 28 August 1979.

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