| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Neurology, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, Illinois 60611, U.S.A.
Theiler's murine encephalomyelitis virus (TMEV) is an enteric pathogen of mice which causes acute and chronic neurological disorders in the natural host. When brain-derived stocks of TMEV isolates are adapted to cell culture they predominantly form either large or small plaques. In this study the type of central nervous system (CNS) infection (acute versus chronic) and the associated disease occurring in mice inoculated intracerebrally with large and small plaque strains of TMEV was investigated.
Large and small plaque strains of TMEV were found to vary in virulence, type of neurological disease produced and ability to establish persistent CNS infection in mice. Two large plaque strains, GDVII and FA viruses, were highly virulent, produced acute encephalitis, but were cleared from the nervous systems of surviving animals. Therefore, it appears that these large plaque variants do not cause persistent CNS infection in mice.
In contrast, five small plaque strains, DA, WW, TO4, Yale and BeAn8386 viruses, were relatively avirulent, usually produced no illness during the first month after inoculation, but readily established persistent CNS infection in mice. Persistently infected mice later developed demyelinating disease. Having identified strains of TMEV that differ regarding their ability to persist, we now hope to be able to exploit this difference in elucidating the basic mechanism(s) of TMEV persistence.
Received 24 May 1979;
accepted 24 August 1979.
This article has been cited by other articles:
|
|
 |
|
  M. Takano-Maruyama, Y. Ohara, K. Asakura, and T. Okuwa Theiler's Murine Encephalomyelitis Virus Leader Protein Amino Acid Residue 57 Regulates Subgroup-Specific Virus Growth on BHK-21 Cells J. Virol., December 15, 2006; 80(24): 12025 - 12031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Mena, J.-P. Roussarie, and M. Brahic Infection of Macrophage Primary Cultures by Persistent and Nonpersistent Strains of Theiler's Virus: Role of Capsid and Noncapsid Viral Determinants J. Virol., December 1, 2004; 78(23): 13356 - 13361. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. W Denton, C. M Tello, and R. W Melvold CD8 + T cells reduce in vitro interferon-g production in Theiler's murine encephalomyelitis virus-induced demyelinating disease model Multiple Sclerosis, August 1, 2004; 10(4): 370 - 375. [Abstract] [PDF]
|
|
|
|
 |
|
 I. Tsunoda, L.-Q. Kuang, J. E. Libbey, and R. S. Fujinami Axonal Injury Heralds Virus-Induced Demyelination Am. J. Pathol., April 1, 2003; 162(4): 1259 - 1269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Palma, R. L. Yauch, H.-K. Kang, H.-G. Lee, and B. S. Kim Preferential Induction of IL-10 in APC Correlates with a Switch from Th1 to Th2 Response Following Infection with a Low Pathogenic Variant of Theiler's Virus J. Immunol., April 15, 2002; 168(8): 4221 - 4230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Tsunoda, Y. Wada, J. E. Libbey, T. S. Cannon, F. G. Whitby, and R. S. Fujinami Prolonged Gray Matter Disease without Demyelination Caused by Theiler's Murine Encephalomyelitis Virus with a Mutation in VP2 Puff B J. Virol., August 15, 2001; 75(16): 7494 - 7505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Obuchi, J. Yamamoto, T. Odagiri, M. N. Uddin, H. Iizuka, and Y. Ohara L* Protein of Theiler's Murine Encephalomyelitis Virus Is Required for Virus Growth in a Murine Macrophage-Like Cell Line J. Virol., May 15, 2000; 74(10): 4898 - 4901. [Abstract] [Full Text]
|
|
|
|
|
|
L. Zhou, Y. Luo, Y. Wu, J. Tsao, and M. Luo Sialylation of the Host Receptor May Modulate Entry of Demyelinating Persistent Theiler's Virus J. Virol., February 1, 2000; 74(3): 1477 - 1485. [Abstract] [Full Text]
|
|
|
|
|
|
C. Badshah, M. A. Calenoff, and K. Rundell The Leader Polypeptide of Theiler's Murine Encephalomyelitis Virus Is Required for the Assembly of Virions in Mouse L Cells J. Virol., January 1, 2000; 74(2): 875 - 882. [Abstract] [Full Text]
|
|
|
|
|
|
C. Martinat, N. Jarousse, M.-C. Prévost, and M. Brahic The GDVII Strain of Theiler's Virus Spreads via Axonal Transport J. Virol., July 1, 1999; 73(7): 6093 - 6098. [Abstract] [Full Text]
|
|
|
|
|
|
B. S. Kim, Y. Y. Bahk, H.-K. Kang, R. L. Yauch, J.-A. Kang, M.-J. Park, and N. M. Ponzio Diverse Fine Specificity and Receptor Repertoire of T Cells Reactive to the Major VP1 Epitope (VP1230-250) of Theiler's Virus: V{beta} Restriction Correlates with T Cell Recognition of the C-Terminal Residue J. Immunol., June 15, 1999; 162(12): 7049 - 7057. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. J. McCright, I. Tsunoda, F. G. Whitby, and R. S. Fujinami Theiler's Viruses with Mutations in Loop I of VP1 Lead to Altered Tropism and Pathogenesis J. Virol., April 1, 1999; 73(4): 2814 - 2824. [Abstract] [Full Text]
|
|
|
|
|
|
N. Jarousse, E. G. Viktorova, E. V. Pilipenko, V. I. Agol, and M. Brahic An Attenuated Variant of the GDVII Strain of Theiler's Virus Does Not Persist and Does Not Infect the White Matter of the Central Nervous System J. Virol., January 1, 1999; 73(1): 801 - 804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Nedellec, P. Vicart, C. Laurent-Winter, C. Martinat, M.-C. Prevost, and M. Brahic Interaction of Theiler's Virus with Intermediate Filaments of Infected Cells J. Virol., December 1, 1998; 72(12): 9553 - 9560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Begolka, C. L. Vanderlugt, S. M. Rahbe, and S. D. Miller Differential Expression of Inflammatory Cytokines Parallels Progression of Central Nervous System Pathology in Two Clinically Distinct Models of Multiple Sclerosis J. Immunol., October 15, 1998; 161(8): 4437 - 4446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Jarousse, S. Syan, C. Martinat, and M. Brahic The Neurovirulence of the DA and GDVII Strains of Theiler's Virus Correlates with Their Ability To Infect Cultured Neurons J. Virol., September 1, 1998; 72(9): 7213 - 7220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wada, I. J. McCright, F. G. Whitby, I. Tsunoda, and R. S. Fujinami Replacement of Loop II of VP1 of the DA Strain with Loop II of the GDVII Strain of Theiler's Murine Encephalomyelitis Virus Alters Neurovirulence, Viral Persistence, and Demyelination J. Virol., September 1, 1998; 72(9): 7557 - 7562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Takata, M. Obuchi, J. Yamamoto, T. Odagiri, R. P. Roos, H. Iizuka, and Y. Ohara L* Protein of the DA Strain of Theiler's Murine Encephalomyelitis Virus Is Important for Virus Growth in a Murine Macrophage-Like Cell Line J. Virol., June 1, 1998; 72(6): 4950 - 4955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. S. Kim, R. L. Yauch, Y. Y. Bahk, J.-A. Kang, M. C. Dal Canto, and C. K. Hall A Spontaneous Low-Pathogenic Variant of Theiler's Virus Contains an Amino Acid Substitution within the Predominant VP1233-250 T-Cell Epitope J. Virol., February 1, 1998; 72(2): 1020 - 1027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Adami, A. E. Pritchard, T. Knauf, M. Luo, and H. L. Lipton A Determinant for Central Nervous System Persistence Localized in the Capsid of Theiler's Murine Encephalomyelitis Virus by Using Recombinant Viruses J. Virol., February 1, 1998; 72(2): 1662 - 1665. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
