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Persistent Infection of a Cell Line of Mouse Origin after Cell Fusion by u.v.-inactivated Sendai Virus

Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, London, WC2A 3PX, U.K., and Department of Medical Microbiology, Welsh National School of Medicine, Heath Park, Cardiff, CF4 4XN, U.K.

A cell line derived from Sendai virus-induced fusion of human adenocarcinoma and CBA mouse embryo cells had Sendai virus antigen (detected by immunofluorescence), together with bi-armed marker chromosomes, in 100% of the cells. After repeated passage, antigen-free cells carrying the same marker chromosomes appeared in the culture. Acrylamide gel analysis showed that all the Sendai virus antigens of antigen-positive cells were normal with the exception of the M protein. Antigen-negative cells contained no virus proteins and could be superinfected with wild-type virus, when all virus proteins appeared.

^* Present address: University of Michigan School of Medicine, Rackham Arthritis Unit, Kresge Building, Ann Arbour, Michigan 48109, U.S.A.

Received 27 June 1979; accepted 29 August 1979.