J Gen Virol
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J Gen Virol 46 (1980), 227-236; DOI 10.1099/0022-1317-46-1-227
© 1980 Society for General Microbiology
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Interferon Effects on Friend Leukaemia Cells. I. Expression of Virus and Erythroid Markers in Untreated and Dimethyl Sulphoxide-treated Cells

Antonina Dolei1, Giulia Colletta2, Maria Rosaria Capobianchi1, Giovanni Battista Rossi3 and Giancarlo Vecchio2

1 Istituto di Virologia, University of Rome, Rome, Italy
2 Cattedra di Virologia Oncologica and Centro di Endocrinologia e Oncologia Sperimentale del CNR, 2â Facoltà di Medicina e Chirurgia, University of Naples, Naples, Italy
3 Cattedra di Microbiologia, University of Rome, and Istituto Superiore di Sanità, Rome, Italy

The effects of low doses (40 to 1000 units/ml) of mouse interferon (IF) on the expression of Friend leukaemia virus (FLV) and globin genes in Friend leukaemia cells (FLC) have been examined. IF blocks production of extracellular virus, but virus antigens accumulate in the cytoplasm. In cells treated with IF at the time of seeding, there is a reduction in the amount of RNA specified by the lymphatic leukaemia virus (LLV) component of FLV; with the same IF dose there is a small but definite stimulation of haemoglobin and globin mRNA synthesis. The effects of IF on LLV gene expression are even more pronounced in dimethyl sulphoxide (DMSO)-stimulated FLC. No correlation was found between LLV gene expression and the appearance of erythroid markers.

Received 9 January 1979; accepted 31 August 1979.


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