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The Structural Relatedness of the Virus Core Proteins of Rauscher and Moloney Murine Leukaemia Virus

The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Department of Biology, Section of Tumor Virology, Houston, Texas 77030, U.S.A.

The virus core proteins p30, p15, pp12 and p10 of Rauscher (R-MuLV) and Moloney murine leukaemia virus (Mo-MuLV) were purified. Two-dimensional peptide maps of ³H-leucine-containing tryptic peptides as well as elution profiles from ion-exchange chromatography of tryptic peptides derived from ³H-tyrosine-labelled R-MuLV core proteins and ¹⁴C-tyrosine-labelled Mo-MuLV core proteins were compared. The results show that the p30 and p10 proteins are very similar but that p15 and pp12 exhibit significant differences.

Received 31 July 1979; accepted 9 October 1979.