HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Howard, D. K. Articles by Schlom, J. Search for Related Content PubMed PubMed Citation Articles by Howard, D. K. Articles by Schlom, J. Agricola Articles by Howard, D. K. Articles by Schlom, J.

Differential Host Ranges for in vitro Infectivity of Mouse Mammary Tumour Viruses

Laboratory of Viral Carcinogenesis, National Cancer Institute, National Institutes of Health, Building 37, Room 1B19, Bethesda, Maryland 20205, U.S.A.

Host-range variants of mouse mammary tumour viruses (MMTVs) have previously been shown to productively infect cells of several species in vitro (Howard & Schlom, 1978). We report here that cell lines have been identified which exhibit differential restriction for replication of different MMTV variants. In addition, a cell line has been identified that changes as a function of passage in culture from being permissive to being restrictive to infection with MMTVs. MMTVs propagated in both murine and non-murine cells retained their antigenic reactivities in a group-specific radioimmunoassay for MMTVs and demonstrated no evidence for the presence of type-C viruses as determined by a variety of techniques. These studies thus establish in vitro cell substrate tropisms that can be used to differentiate between MMTVs.

^* To whom requests for reprints should be addressed.

Received 21 August 1979; accepted 14 November 1979.