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J Gen Virol 47 (1980), 485-488; DOI 10.1099/0022-1317-47-2-485
© 1980 Society for General Microbiology

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Cellular Differences in the Molecular Mechanisms of Vaccinia Virus Host Range Restriction

Dennis E. Hruby*, Debra L. Lynn{dagger}, Richard C. Condit{ddagger} and Joseph R. Kates{dagger}

Department of Microbiology Health Sciences Center State University of New York, Stony Brook, New York 11794, U.S.A.

The biochemistry of vaccinia virus replication in two permissive (BSC-40, L-929), and two non-permissive (CHO, MDBK) cell lines has been compared. While CHO and MDBK cells differentially allowed expression of the various stages in the vaccinia developmental programme, neither cell supported production of any infectious progeny virions.

* Present address: Biophysics Laboratory, University of Wisconsin-Madison, Madison, Wisconsin 53706, U.S.A.

{dagger} Present address: Department of Cellular Biology, Scripps Clinic and Research Foundation, La Jolla, California 92037, U.S.A.

{ddagger} Present address: Department of Biochemistry, Schools of Medicine and Dentistry, State University of New York, Buffalo, New York 14214, U.S.A.

Received 3 August 1979; accepted 15 October 1979.


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