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Persistent Paramyxovirus Infections and Behaviour of -Adrenergic Receptors in C-6 Rat Glioma Cells

Institut für Virologie und Immunbiologie der Universität Würzburg, Versbacher Landstrasse 7 D-8700 Würzburg, West-Germany

This paper describes the influence of persistent infections of C-6 rat glioma cells by paramyxoviruses [virus of subacute sclerosing panencephalitis (SSPE) and canine distemper (CDV)] on the cellular -adrenergic membrane receptors. The number and binding properties of the -adrenergic receptors of the paramyxovirus-infected cells were measured by ³H-dihydroalprenolol binding studies and compared with those of the uninfected C-6 cells. In the case of SSPE virus neither changes in number nor binding properties of -adrenergic receptors could be observed, whereas in the case of CDV persistence the number of -adrenergic receptors was reduced to about 50%, without an apparent influence on the binding constant for the ligand to the receptors.

Received 30 August 1979; accepted 9 November 1979.

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