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Isolation of a New Strain of Cytomegalovirus from Explanted Normal Skin

Department of Pediatrics and Children's Hospital Research Foundation, 700 Children's Drive Columbus, Ohio 43205, U.S.A.

James R. Blakeslee, Jun.

Department of Veterinary Pathobiology The Ohio State University, 1925 Coffey Drive Columbus, Ohio 43210, U.S.A.

Eng-Shang Huang

Cancer Research Center and Department of Medicine University of North Carolina, Chapel Hill North Carolina 27514, U.S.A.

Forty-three fibroblast cell lines were initiated from normal skin biopsies. One cell line from a patient with Charcot-Marie-Tooth disease (CMT) spontaneously developed c.p.e. suggestive of cytomegalovirus (CMV). Characterization of the virus showed it to be a new strain of CMV and the results suggested that skin fibroblasts from CMT patients may carry latent CMV.

Received 12 September 1979; accepted 14 November 1979.