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A Sensitive Method for Quantification of Vesicular Stomatitis Virus Defective Interfering Particles: Focus Forming Assay

Harshad R. Thacore

Department of Microbiology School of Medicine State University of New York at Buffalo, Buffalo, New York 14214, U.S.A.

A focus-forming assay for the quantification of defective interfering (DI) particles of vesicular stomatitis virus (VSV) is described. This assay is based on the procedure described for lymphocytic choriomeningitis (LCM) virus by Popescu et al. (1976). Under appropriate conditions this focus-forming assay can quantify fewer than 100 DI particles/ml in a preparation containing a large number of infectious particles.

^* Present address: Microbiology Section, U-44, University of Connecticut, Storrs, Connecticut 06268 U.S.A.

To whom requests for reprints should be addressed.

Received 1 November 1979; accepted 11 December 1979.