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Cell-mediated Immunity in Herpes Simplex Virus-infected Mice: Induction, Characterization and Antiviral Effects of Delayed Type Hypersensitivity

Division of Virology, Department of Pathology, University of Cambridge, Laboratories Block, New Addenbrooke's Hospital, Hills Road, Cambridge, U.K.

Delayed type hypersensitivity (DTH) was induced in mice sensitized with an intradermal inoculation of herpes simplex virus type 1 (HSV-1). The reaction was observed 4 to 5 days p.i. and could still be induced up to 18 months later. In contrast, the adoptive transfer of DTH using draining lymph node cells was only possible during the period 6 to 10 days p.i. The cells taken at these times also contained mediators of antiviral immunity, as determined by a marked reduction of virus titres in the ears of infected animals 1 to 3 days after transfer. Draining lymph node cells taken at later times contained mediators of virus immunity, but titres were not reduced until day 5 after the transfer. The cell type involved in both the DTH and antiviral activity was a T lymphocyte, although the particular T cell subsets involved have yet to be determined.

Received 1 October 1979; accepted 11 January 1980.

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