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Interferon Induction by Viruses. Sindbis Virus: Defective-interfering Particles Temperature-sensitive for Interferon Induction

Microbiology Section, U-44 Biological Sciences Group University of Connecticut Storrs, Connecticut 06268, U.S.A.

A defective-interfering (DI) particle of Sindbis virus was generated from a ts mutant of RNA^- complementation group A by serially undiluted passages at 30 °C. This mutant induced interferon at a permissive temperature (30 °C), but not at a non-permissive temperature (40.5 °C); it also expressed homotypic interference throughout the range 30 to 40.5 °C. This demonstrates for the first time in a DI particle a ts function, namely, the ability to induce interferon. In addition, our data provide further evidence that the RNA genome of a Sindbis DI particle can be translated within the cell. We postulate that the products of translation function to produce the putative inducer of interferon, namely a molecule of dsRNA.

Received 6 September 1979; accepted 30 December 1979.

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