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Effect of Acyclovir on Recurrence of Herpes Simplex Skin Lesions in Mice

Department of Bacteriology The Medical School University Walk, Bristol BS8 1TD, U.K.

Acyclovir (ACV) was effective in preventing recurrence of herpes simplex in mice whose skin was stripped with cellophane tape. Treatment with ACV did not eliminate latent herpes simplex virus from the cervical ganglia.

Received 2 November 1979; accepted 4 January 1980.

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