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Isolation and Characterization of Acyclovir-resistant Mutants of Herpes Simplex Virus

Division of Virology, Department of Pathology, University of Cambridge, Cambridge, England

Mutants of HSV which are resistant to acyclovir (acycloguanosine) have been isolated following serial passages of several herpes simplex virus (HSV) strains in the presence of the drug. The majority of the mutants isolated are defective in induction of thymidine kinase (TK) and this is consistent with the observation that independently isolated TK^- viruses are naturally resistant to ACV. One mutant is described (SC16 R₉C₂) which is resistant in biochemically transformed cells which express HSV TK. This suggests that its resistance resides at a level other than TK. It is also resistant to phosphonoacetic acid, suggesting that the DNA polymerase locus may be involved. A further mutant is described [Cl (101) P₂C₅] which induces normal levels of TK, although the nature of resistance of this virus is not yet elucidated.

Received 5 December 1979; accepted 12 February 1980.

This article has been cited by other articles:

				R. G. Kost, E. L. Hill, M. Tigges, and S. E. Straus Recurrent Acyclovir-Resistant Genital Herpes in an Immunocompetent Patient N. Engl. J. Med., December 9, 1993; 329(24): 1777 - 1782. [Full Text]