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Early Replication of Friend Leukaemia Viruses in Spleen Macrophages

Institutes of Microbiology and General Pathology, University of Pisa, 56100 Pisa, Italy

The ability of spleen macrophages to support Friend leukaemia virus replication was studied by testing for infectivity in adherent cells obtained from mice at various times after infection. Virus-releasing macrophages appeared early after infection and reached a high proportion. The released virus was probably synthesized de novo since macrophage infectivity was strongly reduced by treatments which affected cellular viability or synthetic activities and electron microscopy showed C-type particles budding from macrophages.

Received 23 October 1979; accepted 15 January 1980.