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Growth of Bacteriophage X-174 at Elevated Temperatures

Department of Microbiology, University of Massachusetts, Amherst, Massachusetts 01003, U.S.A.

The replication of bacteriophage X-174 is impaired at temperatures above 40 °C. Mutants (ht) that replicate at high temperature were isolated and partially characterized. Wild-type X fails to grow at high temperature because, unlike the mutants, it does not make appreciable amounts of single-stranded (ss)DNA. An unusual form of ssDNA, not found in complete virions, is described.

^* Present address: Institute of Molecular Biology, State University of Utrecht, Padualaan 8, 3508 TB Utrecht, The Netherlands.

Received 16 November 1979; accepted 23 January 1980.

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