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J Gen Virol 49 (1980), 411-416; DOI 10.1099/0022-1317-49-2-411
© 1980 Society for General Microbiology
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Characterization of X-tropic Endogenous Retrovirus-specific RNA in Uninfected Tissues and Lymphosarcoma of BALB/c Mice

Barid B. Mukherjee and Pamela M. Mobry

Department of Biology, McGill University, 1205 avenue Docteur Penfield Montreal, Quebec, Canada H3A 1B1

Robert N. Vincent

Montreal Children's Hospital, Paediatrics Department, Montreal, Quebec, Canada H3H 1P3

Analysis of endogenous X-tropic BALB/c retrovirus-specific RNAs in a BALB/c mouse tissue containing mostly non-dividing cells (liver), in two normal tissues having significant proportions of dividing cells (20-h regenerating liver and 12-day embryo) and in cells of a lymphosarcoma of BALB/c mice were carried out by determining the extent to which the RNAs from these tissues hybridized to the virus 3H-cDNA probe and by their relative sedimentation values in a sucrose gradient. RNAs from 20-h regenerating liver, 12-day embryo and lymphosarcoma, each containing a significant proportion of proliferating cells, showed 8 to 21% higher hybridization values than normal liver RNA. Differences in the exact size classes of virus-specific RNAs and, in their relative proportions were found to exist in the four different tissue types examined and no correlation between a specific RNA size-profile and the proliferating activity of a tissue could be detected.

Received 17 July 1979; accepted 12 February 1980.




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