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Differentiation of Rubella Virus Strains by Neutralization Kinetics

Wellcome Research Laboratories, Beckenham, Kent, U.K.

The neutralization of rubella virus was investigated and shown to proceed by first order kinetics over the first 10 to 15 min. A comparison of the rate constant of neutralization (K) for six strains of rubella virus was carried out over this period of the reaction. Two particularly antibody-sensitive isolates were detected. It was noted that the three strains isolated from in utero infections were poorly neutralized by heterologous antisera when compared to postnatal strains.

Received 12 November 1979; accepted 20 February 1980.

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