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J Gen Virol 49 (1980), 427-431; DOI 10.1099/0022-1317-49-2-427
© 1980 Society for General Microbiology
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The Effect of {Delta}-9-Tetrahydrocannabinol on Herpes Simplex Virus Replication

R. Dean Blevins and Michael P. Dumic

Department of Biological Sciences Division of Health Sciences East Tennessee State University, Johnson City, Tenn. 37601, U.S.A.

Both herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) failed, in an identical fashion to replicate and produce extensive c.p.e. in human cell monolayer cultures which were exposed (8 h before infection, at infection, or 8 h p.i.) to various concentrations of {Delta}-9-tetrahydrocannabinol. Similar results were obtained with a plaque assay utilizing confluent monkey cells. Possible mechanisms for this antiviral activity are discussed.

Received 25 January 1980; accepted 26 February 1980.




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