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A Comparative Study on the u.v. Resistance of Double-stranded and Single-stranded Encephalomyocarditis Virus RNAs: Evaluation of the Possible Contribution of Host-mediated Repair

Department of Virology and A. N. Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State University, and Institute of Poliomyelitis and Viral Encephalitides, the U.S.S.R. Academy of Medical Sciences, Moscow, U.S.S.R.

To reveal previously suggested host-mediated repair of u.v.-induced lesions in dsRNA of encephalomyocarditis (EMC) virus, two sets of experiments have been carried out: (i) samples of dsRNA of EMC virus were irradiated with different doses of u.v. light and their infectivity was assayed in Krebs II cells, before and after conversion of dsRNA into a ss form; (ii) samples of ssRNA of EMC virus were similarly irradiated and their infectivity was assayed before and after conversion of ssRNA into a ds form. No evidence for a significant host-mediated repair of dsRNA in this virus-cell system has been obtained.

Received 11 December 1979; accepted 5 March 1980.