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Simian Virus 40 and Moloney-Murine Sarcoma Virus Infection of Bona fide Mouse Epithelium

Cell Culture Laboratory School of Public Health University of California, Berkeley, California, U.S.A.

Moloney-murine sarcoma virus (Moloney-MSV) and simian virus 40 (SV40) were found to infect successfully pure cultures of epithelial cells established from mouse liver and mammary tissue. MSV infection resulted in transient morphological foci with persistent production of infectious virus. SV40 infection produced detectable levels of virus-specific T antigen in the cells but morphological transformants were not observed.

^* Present address: Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164, U.S.A.

Received 21 December 1979; accepted 6 March 1980.