HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kato, N. Articles by Kobayashi, T. Search for Related Content PubMed PubMed Citation Articles by Kato, N. Articles by Kobayashi, T. Agricola Articles by Kato, N. Articles by Kobayashi, T.

Depressors of Interferon Synthesis: Further Studies on the Production, Action and Properties of the So-called Enhancer

Institut für Virologie, Justus Liebig-Universität, Giessen, Germany

F. Ohta and T. Kobayashi

Department of Bacteriology, Nagoya University School of Medicine, Nagoya, Japan

Mode of action, production and some properties of a viral growth-enhancing factor (enhancer) which was detected in allantoic fluids of eggs infected with parainfluenza type 1 virus were investigated. The factor markedly depressed interferon synthesis induced by u.v.-irradiated Newcastle disease virus in chick embryo cells, but did not inhibit the action of exogenous interferon. It had no effect on the multiplication of Newcastle disease virus in chick embryo cells. The depression of interferon synthesis by the factor was unlikely, therefore, to be due to an inhibition of the early steps of virus cell interaction. On the basis of its biological properties the factor should be termed ‘interferon depressor’. The appearance of the factor in allantoic fluids of eggs infected with parainfluenza type 1 virus could be determined by selectively destroying the interferon also contained in the materials. The activity of the factor reached a peak 24 hr after virus inoculation and remained stationary thereafter. Present data on the chemical nature of the factor are compatible with the view that it is a carbohydrate.

Received 18 November 1968; accepted 3 March 1969.