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Effect of Temperature on the Multiplication of an Influenza Virus

Institut für Virologie, Justus Liebig-Universität, Giessen, Germany

The temperature characteristic of the RNA-dependent RNA polymerase induced after infection with fowl plague virus was determined. At temperatures below 34° the energy of activation in vitro was 16 kcal./mol. greater than above this temperature. The rate of synthesis of virus haemagglutinin and neuraminidase decreased rapidly below 34°. At low temperatures the activity of the virus RNA polymerase may be rate limiting for virus multiplication. At 41° the virus RNA polymerase was unstable in vitro as well as in vivo. The synthesis of virus haemagglutinin and neuraminidase, however, was unimpaired. At 44° virus subunits were not produced. The host cells withstood 44° without any irreversible harm during the time of the experiment. It is uncertain whether or not at elevated temperatures the activity of the viral RNA polymerase was also rate limiting.

Received 28 January 1969; accepted 31 March 1969.