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Local and Systemic Protection by Synthetic Polyanionic Interferon Inducers in mice against Intranasal Vesicular Stomatitis Virus

Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 U.S.A.

The effects of the synthetic polyanionic interferon inducers maleic acid/divinyl ether copolymer (MA/DVE) and polyinosinic/polycytidylic acid (polyrI/polyrC) were studied in mice challenged intranasally with vesicular stomatitis virus. Young (14-day or 24-day) animals were used. Either local (intranasal) or systemic (intraperitoneal) treatment protected significantly against virus infection. Optimal local protection was given by 40 µg. of polyrI/polyrC instilled 4 hr before virus challenge. Intraperitoneal MA/DVE exerted a more durable effect lasting for at least 10 days, and polyrI/polyrC proved to be active when applied several days after inoculation of virus. PolyrI/polyrC treatment started after virus in the brain had reached maximum concentration retarded progression of the disease, but when delayed until clinical signs of illness occurred, polyrI/polyrC treatment was not effective. The protective activity of MA/DVE and polyrI/polyrC injected intraperitoneally against virus infection at a distant site suggested the mediation by a systemic antivirus state, presumably due to interferon production.

Received 28 January 1969; accepted 10 May 1969.

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