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Depressors of Interferon Synthesis: Inhibition of Interferon Synthesis by Chick Allantoic Mucopolysaccharide, Capsular Polysaccharide of Klebsiella pneumoniae and Heparin

Institut für Virologie, Justus Liebig-Universität, Giessen, Germany

Three kinds of polyanionic polysaccharides, chick allantoic mucopolysaccharide, capsular polysaccharide of Klebsiella pneumoniae and heparin depressed interferon synthesis induced by ultraviolet-irradiated Newcastle disease virus in chick embryo cells. The minimum concentrations causing complete inhibition of interferon synthesis were respectively 20, 0.5 and 50 µg./ml. The polysaccharides did not affect the action of exogenous interferon at concentrations sufficient to depress interferon synthesis. It seems unlikely that these polysaccharides were toxic for the cells, and that the depression of interferon synthesis was due to an inhibition of the early steps of virus-cell interaction.

^* Permanent address: Department of Bacteriology, Nagoya University School of Medicine, Nagoya, Japan.

Received 18 November 1968; accepted 6 June 1969.

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