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Inactivation of Respiratory Syncytial Virus in Aerosol

Laboratory of Microbiology, State University, Catharijnesingel 59, Utrecht, The Netherlands

Aerosols of respiratory syncytial virus were kept at different relative humidities (RH). Viability was studied by a plaque method. Virus recoveries 1 min. after aerosolization were highest at high RH. The stability of the aerosol was maximal at 60% RH. The total decay after 61 min. varied from 1.1 log. p.f.u. to 2.5 log. p.f.u., with peak values at 30% RH (2.3 log. p.f.u.) and 80% RH (2.5 log. p.f.u.), suggesting two processes with different kinetics. Oxidation was excluded as a cause of inactivation by experiments in pure nitrogen.

^* Present address: National Institute of Public Health, Sterrenbos 1, Utrecht, The Netherlands.

Received 18 November 1968; accepted 17 June 1969.

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