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Further Studies on the Differences in the Interaction of Simian Virus 40 with African Green Monkey Kidney and Human Diploid Cells

The Wistar Institute of Anatomy and Biology, 36th Street at Spruce Philadelphia, Pennsylvania 19104

Infection of human diploid cells with Simian virus 40 (SV 40) leads to an abortive virus cycle characterized by little virus production, little or no cell destruction, no inhibition of cell replicating capacity, low efficiency of induction of tumour antigen (T-antigen) and eventual transformation of the morphological, chromosomal, and growth characteristics of the cells (Koprowski et al. 1962; Shein & Enders, 1962; Rabson et al. 1962; Weinstein & Moorhead, 1965). In marked contrast, in stationary-phase primary African green monkey kidney (GMK) cells, SV 40 infection leads to high yields of virus, highly efficient induction of T-antigen and extensive cell destruction (Carp & Gilden, 1966). The determination of the cause of these marked differences might clarify the mechanism of the transformation process. Previous results indicated that the virus adsorbed and entered into eclipse phase with equal efficiency for the two cell types (Carp & Gilden, 1966).

^* Present address: Institute for Basic Research in Mental Retardation, 1050 Forest Hill Road, Staten Island, New York 10314

Received 26 February 1969; accepted 15 May 1969.