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Further Studies on the Inactivation of the Scrapie Agent by Ultraviolet Light

Agricultural Research Council Institute for Research on Animal Diseases, Compton, Nr Newbury, Berkshire

Elizabeth Blum and Tikvah Alper

Medical Research Council Experimental Radiopathology Research Unit Hammersmith Hospital, London, W.12

We have exposed suspensions containing the infective agent of scrapie to doses of ultraviolet light (u.v.) up to 12 times greater than those used in the experiments reported by Alper et al. (1967). Suspensions were prepared and assayed by the methods described by those authors and by Alper, Haig & Clarke (1966). Two different suspensions were irradiated on 2 days separated by a week and were exposed to nearly monochromatic u.v. at 254 nm. from a 15 w ‘germicidal’ lamp. All of the samples were assayed in duplicate and about the same level of activity remained after similar doses in both experiments (Fig. 1). Ultraviolet absorption spectra taken on several preparations made at various times, were constant within fairly narrow limits. Transmittances of the total samples (thickness 2 mm.) irradiated were 0.93. Samples were stirred during irradiation.

Received 21 April 1969; accepted 28 June 1969.

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