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J Gen Virol 50 (1980), 173-178; DOI 10.1099/0022-1317-50-1-173
© 1980 Society for General Microbiology
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Studies on Recombination in Heterologous Crosses of Rous Sarcoma Virus

P. C. Balduzzi, J. R. Christensen and M. F. D. Notter

Department of Microbiology The University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, U.S.A.

Ts mutants in src from the Prague and Schmidt-Ruppin strains of Rous sarcoma virus (RSV) were used to superinfect chicken and quail cells chronically infected with the Bryan strain of RSV. No wild-type recombinants and few double-defective virions were produced. These results indicate that genetic recombination does not occur with high frequency in these heterologous crosses even if all infectious virus is derived from doubly infected cells.

Received 27 September 1979; accepted 6 March 1980.




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