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Biochemical Characterization of the Virus Causing Leukoencephalitis and Arthritis in Goats

¹ Department of Neurology and
² Department of Comparative Medicine The Johns Hopkins University School of Medicine, Baltimore, Md. 21205, U.S.A.

Goat leukoencephalitis-arthritis virus (GLV) has the density of a retrovirus in sucrose and contains an endogenous RNA-dependent DNA polymerase (reverse transcriptase). The virion reverse transcriptase utilizes the synthetic RNA template poly(rA).(dT)₁₂ but not the synthetic DNA template poly(dA).(dT)₁₂. A high mol. wt. RNA similar in size to visna virus RNA was isolated from ³H-uridine-labelled virions. The major structural protein of GLV has the same mol. wt. as that of visna virus. From these data the GLV appears to be a retrovirus.

Received 6 February 1980; accepted 18 April 1980.

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