J Gen Virol
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J Gen Virol 50 (1980), 437-440; DOI 10.1099/0022-1317-50-2-437
© 1980 Society for General Microbiology
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Production of Chick Interferon by Reactivating Chick Erythrocytes

D. C. Burke

Department of Biological Sciences University of Warwick, Coventry, CV4 7AL U.K.

T. Ege and N. R. Ringertz

Institute for Medical Cell Research and Genetics Karolinska Institute, Stockholm Sweden

When chick erythrocytes were fused with mouse L929 or A9 cells and the heterokaryons induced for interferon production on consecutive days, considerable amounts of mouse interferon were produced every day. Small amounts of chick interferon were produced 2 to 3 days after fusion, coincident with the appearance of a chick enzyme, appearance of nucleoli and increase in chick cell nuclear diameter.

Received 22 October 1979; accepted 28 April 1980.




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