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J Gen Virol 50 (1980), 447-450; DOI 10.1099/0022-1317-50-2-447
© 1980 Society for General Microbiology
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Induction of {Delta}43 Ketosteroid Synthesis by Interferon in Mouse Adrenal Tumour Cell Cultures

C. Chany, D. Mathieu and A. Gregoire

Institute de Recherches Scientifiques sur le Cancer, C.N.R.S., B.P. 8 Villejuif, France

Interferon, like cholera toxin, induces in mouse adrenal Y1 cells the production of {Delta}43 ketosteroids. In parallel, cyclic AMP (cAMP) is activated. At high concentrations, mouse but not human interferon induces a cell rounding effect, similar to that obtained with cholera toxin. In Y1 cells transformed by simian adenovirus 7, production of cAMP is still increased but that of steroids is blocked. The role of interferon in these cellular events is discussed.

Received 4 February 1980; accepted 16 May 1980.




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