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J Gen Virol 51 (1980), 171-177; DOI 10.1099/0022-1317-51-1-171
© 1980 Society for General Microbiology
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Varicella-Zoster Virus Transformation of Hamster Embryo Cells

Lawrence D. Gelb, John J. Huang and Wanda J. Wellinghoff

Howard Hughes Medical Institute Laboratory Departments of Medicine, Microbiology and Immunology Washington University School of Medicine, St Louis, Missouri 63110, U.S.A.

Varicella-zoster virus infection of primary hamster embryo cells resulted in oncogenic transformation. These transformed cells exhibited virus-specific antigens by immunofluorescence and developed surface Fc receptors. They induced aggressive fibrosarcomas when injected into inbred hamsters. The tumour-bearing hamsters develop antibodies to varicella-zoster antigens.

Received 21 December 1979; accepted 5 June 1980.




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