J Gen Virol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 51 (1980), 189-193; DOI 10.1099/0022-1317-51-1-189
© 1980 Society for General Microbiology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Iwasaka, T.
Right arrow Articles by Oda, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iwasaka, T.
Right arrow Articles by Oda, H.
Agricola
Right arrow Articles by Iwasaka, T.
Right arrow Articles by Oda, H.

Tubular Structures in Mixed Infection with Herpes Simplex Virus Type 1 and Type 2

T. Iwasaka1 and R. Mori1

1 Department of Microbiology, School of Medicine Kyushu University, Fukuoka 812, Japan

H. Oda2

2 Department of Bacteriology, School of Medicine Kagoshima University, Kagoshima 890, Japan

The nature of tubular structures (TS) specifically found in cells infected with herpes simplex virus type 2 (HSV-2) was investigated by studying the appearance of TS in mixed infections with herpes simplex virus type 1 (HSV-1) and HSV-2 in Vero cells. Mixed infections with HSV-1 and HSV-2 resulted in a notable reduction in TS appearance. Accumulation of TS in cells infected with u.v.-irradiated HSV-2 was decreased by superinfection with HSV-1. The majority of progeny viruses obtained from mixed infection with HSV-1 and HSV-2 was neutralized by type-specific anti-HSV-2 serum, but not by type-specific anti-HSV-1 serum. Analysis of the genotype of the progeny revealed that the yield from mixed infection contained both HSV-1 and HSV-2 genotypes. These observations indicate that the majority of HSV-1 progeny of mixed infection is phenotypically mixed and make it possible to propose that TS are materials related to the type-specific antigen for HSV-2 which can be utilized by superinfection with HSV-1, producing phenotypically HSV-2 particles.

Received 29 March 1980; accepted 5 June 1980.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1980 by the Society for General Microbiology.