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J Gen Virol 51 (1980), 207-211; DOI 10.1099/0022-1317-51-1-207
© 1980 Society for General Microbiology
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Proteolytic Activation of the Haemagglutinin-Neuraminidase of Newcastle Disease Virus Involves Loss of a Glycopeptide

W. Garten, T. Kohama and H.-D. Klenk

Institut für Virologie Fachbereich Humanmedizin der Justus-Liebig-Universität Giessen, Frankfurter Str. 107 6300 Giessen, Germany

The uncleaved (HN0) and the cleaved (HN) forms of the haemagglutinin-neuraminidase glycoprotein of Newcastle disease virus (NDV), strain Ulster, were analysed by polyacrylamide gel electrophoresis under reducing and non-reducing conditions. When HN0 is converted into HN, a glycopeptide with an apparent mol. wt. of about 8000, which is not found in the mature spike, is removed.

Received 10 April 1980; accepted 10 June 1980.




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