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Formation and Characterization of an Intertypic Lymphocytic Choriomeningitis Recombinant Virus

P. Cash^1,

¹ Department of Microbiology The Medical School University of Alabama in Birmingham, Birmingham, Alabama 35294, U.S.A.
² U.S. Army Medical Research Institute of Infectious Diseases Fort Detrick Frederick, Maryland 21701, U.S.A.

An intertypic reassortant arenavirus has been obtained from co-infection of BHK-21 cells by two strains of lymphocytic choriomeningitis virus (LCM virus), WE and Armstrong (ARM), having the large/small (L/S) viral RNA genotype of WE/ARM. The two parental viruses have different virulence characteristics in hamsters and guinea-pigs. The reassortant virus induces LCM-WE-type plaques in Vero cell monolayers, but has the avirulent characteristics of LCM-ARM in hamsters and two strains of guinea-pigs. These results suggest that the LCM plaque phenotype is determined by L RNA gene products, while the pathogenic potential in guinea-pigs may be determined by S RNA gene products.

^* Present address: Department of Microbiology, Medical Center, University of West Virginia, Morgantown, West Virginia, 2505, U.S.A.

Present address: Department of Bacteriology, University of Aberdeen, Foresterhill, Aberdeen, Scotland.

Received 18 April 1980; accepted 10 June 1980.

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