HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mayo, D. R. Articles by Rapp, F. Search for Related Content PubMed PubMed Citation Articles by Mayo, D. R. Articles by Rapp, F. Agricola Articles by Mayo, D. R. Articles by Rapp, F.

Leukaemia Reactivates Mouse Cytomegalovirus

Fred Rapp

Department of Microbiology and Specialized Cancer Research Center The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, U.S.A.

An established model for latency by mouse cytomegalovirus (MCMV) was used to assess the effects of leukaemia on reactivation of MCMV. After inoculation of 400 spleen focus-forming units of Friend leukaemia virus (FLV), a significant number of mice yielded MCMV in salivary glands and kidneys 4 to 5 weeks later. Administration of cyclophosphamide during FLV infection increased the percentage of MCMV-positive animals. These results suggest that cytomegalovirus infections in leukaemia patients may reactivate as a result of the leukaemia itself and may be exacerbated by chemotherapy.

^* Present address: Virology Laboratory, Veterans Administration Medical Center, West Haven, Connecticut 06516, U.S.A.

To whom reprint requests should be addressed.

Received 29 April 1980; accepted 28 April 1980.