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Proteins of Herpesvirus Saimiri: Identification of Two Virus Polypeptides Released into the Culture Medium of Productively Infected Cells

National Institute for Medical Research Mill Hill, London NW7 1AA, U.K.

Two virus-induced polypeptides are preferentially released into the culture medium of owl monkey kidney cells productively infected with herpesvirus saimiri (HVS). These polypeptides have apparent mol. wt. of 160 x 10³ and 28 x 10³ and are the major virus-induced polypeptides in a membrane fraction from infected cells. Both these excreted polypeptides co-migrate with virus structural proteins and are selectively released from enveloped virus particles by treatment with Nonidet-P40.

Received 6 May 1980; accepted 14 July 1980.