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Interferon Production by Human Lymphoblastoid Cell Lines of Different Origins

¹ Virology R & D The Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K.
² Medical Research Council, Clinical and Population Cytogenetics Unit Western General Hospital, Crew Road, Edinburgh EH4 2XU, U.K.

150 lymphoblastoid cell lines derived from normal individuals or from subjects with various clinical conditions were induced to form interferon by treatment with Sendai virus. Irrespective of the status of the donor, most of the lines produced some interferon and 22 produced considerable amounts (more than 3000 international units/ml). Lines derived from infectious mononucleosis patients were good interferon producers while those from leukaemic donors were poor producers. The data suggest that the clinical conditions of the donor and the source of transforming virus may influence the quantity of interferon produced by a given cell line.

Received 4 February 1980; accepted 24 July 1980.