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Resistance to Interferon of a Human Adenocarcinoma Cell Line, HEC-1, and its Sensitivity to Natural Killer Cell Action

H.-Y. Chen

Department of Microbiology School of Medicine Chiba University, Chiba 280, Japan
¹ Institut Pasteur du Brabant rue de Remorqueur, B-1040 Brussels, Belgium

A human endometrial cancer cell line, HEC-1, was found to be resistant to the antiviral and anticellular action of interferon. However, HEC-1 cells were susceptible to the cytotoxicity of natural killer (NK) cells, and interferon enhanced such NK activity. When HEC-1 cells were treated with interferon, sensitivity of HEC cells to the cytotoxicity of NK cells was not suppressed.

Present address: National Institute of Preventive Medicine, Taipei, Taiwan.

Received 26 June 1980; accepted 29 July 1980.

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