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Interferon Stabilization and Enhancement by Rare Earth Salts

Department of Microbiology The Medical College of Wisconsin, P.O. Box 26509, Milwaukee Wisconsin 53226, U.S.A.

The addition of salts of the rare earth elements (lanthanides) enhances by a factor of two or more the initial activity of human fibroblast, leukocyte and immune interferons as well as mouse L-cell interferon. Furthermore, the salts of the lanthanides (0.01 to 0.002 M) preserve the activity of human fibroblast interferon not only after 4 days of heating at 37 °C but also after exposure to severe shearing forces; human leukocyte interferon was stabilized to a lesser degree, albeit significantly.

Received 4 March 1980; accepted 18 August 1980.