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Interferon-mediated Protein Kinase in Mouse Cells Treated with Iododeoxyuridine (IdUrd) and Induced to Express Endogenous Retroviruses

Viral Oncology Unit Institut Pasteur, 25 rue du Dr Roux 75724 Paris, Cedex 15, France

Treatment of K/Balb cells with IdUrd leads to the expression of endogenous virus and interferon is formed which subsequently can suppress the release of virus into the medium. Under these conditions, a protein kinase activity capable of phosphorylating an endogenous polypeptide of apparent mol. wt. 67000 is detected. This kinase activity is analogous to that induced in K/Balb cells treated with exogenous interferon. The induction of the protein kinase activity in IdUrd-treated K/Balb cells can be blocked by anti-interferon serum, thus providing evidence for the presence and action of interferon.

Received 4 March 1980; accepted 21 August 1980.