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J Gen Virol 52 (1981), 39-48; DOI 10.1099/0022-1317-52-1-39
© 1981 Society for General Microbiology
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Induction of Epstein-Barr Virus Early Antigen, Virus Capsid Antigen and Virus DNA Synthesis by Mitomycin C

Ingemar Ernberg and Martin H. Moar{dagger}

Department of Tumour Biology, Karolinska Institutet, S-10401 Stockholm 60, Sweden

The effect of mitomycin C was tested on Epstein-Barr virus (EBV) antigen and virus DNA synthesis in producer and non-producer cell lines. We found that producer, but not non-producer cell lines, are inducible for early antigen and virus capsid antigen synthesis. Although host DNA synthesis is effectively inhibited by over 99% in the presence of mitomycin C, virus DNA synthesis in the producer lines is unaffected and induced in parallel with the virus antigens.

{dagger} Present address: Department of Zoology, West Mains Road, University of Edinburgh, Scotland.

Received 17 April 1980; accepted 1 August 1980.




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Copyright © 1981 by the Society for General Microbiology.