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The Correlation of Fatty Acid Content of Infected Cells and Virions with Newcastle Disease Virus (NDV) Virulence

¹ Departments of Bacteriology
and² Departments of Virology, Royal Postgraduate Medical School, London W12 0HS, U.K.

Chick embryo fibroblasts (CEF) infected with virulent strains of Newcastle disease virus (NDV) showed a dramatic increase in total unsaturated fatty acids (UFA). This increase was not seen in cells infected with the avirulent strains of NDV, Sendai virus or influenza A (PR8). The virions of the virulent strains of NDV harvested from the chorioallantoic cavity also had a higher UFA content compared to the avirulent ones. The kinetics of UFA increase in the virulent strains could be correlated with published data on the kinetics of RNA and protein synthesis inhibition, polykaryon formation and membrane permeability changes.

Received 27 May 1980; accepted 21 August 1980.