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Studies on an Interferon-sensitive Mutant of Mengovirus: Effects on Host RNA and Protein Syntheses

Department of Biological Sciences Purdue University, West Lafayette Indiana 47907, U.S.A.

Interferon induces an activity which strongly inhibits the growth of is-1, an interferon-response mutant of mengovirus. This activity is not expressed in protected cells infected with either is⁺ (the wild-type parent) or vaccinia virus, or in cells infected with is-1 in the presence of actinomycin D. A failure of is-1 to shut off host RNA and/or protein synthesis could explain these observations. The present paper, however, shows that is-1 and is⁺ are equally effective in suppressing host syntheses, and suggests that is⁺ actively inhibits the interferon-mediated activity directed against is-1.

Received 8 August 1980; accepted 24 September 1980.